Extended Data Fig. 7: RNA-sequencing analysis of dual AAV9 ABE editing of Myh6h403/+ mice.
From: Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice
Volcano plot showing fold-change and p-value of genes up-regulated (red) and down-regulated (blue) in Myh6h403/+ mice compared to Myh6WT mice (top), ABE-treated Myh6h403/+ mice compared to Myh6h403/+ mice (middle), and ABE-treated Myh6h403/+ mice compared to Myh6WT mice (bottom). P-adjust < 0.01 and fold-change > 2.0 were used for cutoffs; p-adjust values are calculated by two-tailed Wilcoxon rank-sum test. n = 3 male mice for each group.
