Extended Data Fig. 3: Characterization of BI_cγ1 and MI_cγ1 mice with additional immunoglobulin chromosomal translocations.

MM development in BI_cγ1 (a) and MI_cγ1 (b) mice carrying immunoglobulin chromosomal translocations (complementary to Fig. 1h-i). c) Characterization of MM development in mice with t(4;14) crossed with lines carrying IKK2^NF-κB activation or MYC expression (complementary to Fig. 1j). d) Quantification of GFP⁺CD138⁺B220⁻sIgM⁻ PCs by flow cytometry in the BM of BI_cγ1 and MI_cγ1 mice at MGUS and MM states, and in YFP_cγ1 control mice at 6 months of age, are shown (complementary to Fig. 1k). e) Representative electrophoresis analyses of immunoglobulin secretion in serum samples from BI_cγ1 and MI_cγ1 mice at MGUS and MM states, and in YFP_cγ1 control mice, are shown. Data is depicted as mean ± s.d.. P values are obtained using one-way ANOVA test followed by Tukey’s multiple comparison test (a and b), Kruskal-Wallis adjusted for multiple comparisons by Dunn’s test (c and d), unpaired t test (a) and Mann-Whitney test (a and b).

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