Extended Data Fig. 7: Association analyses of rare coding variants between cases with POI and in-house controls. | Nature Medicine

Extended Data Fig. 7: Association analyses of rare coding variants between cases with POI and in-house controls.

From: Landscape of pathogenic mutations in premature ovarian insufficiency

Extended Data Fig. 7

The quantile-quantile plot comparing observed versus expected P values for each rare coding variants in 703 genes (cases n = 1,030, controls n = 5,000, one-sided Fisher’s exact test). The dashed line represents the Bonferroni-corrected P <0.05 threshold. EIF2B2 p.Val85Glu is the only variant that significantly associated with POI.

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