Fig. 2: Waning HIV-1-specific cellular and humoral immune responses before and after ATI. | Nature Medicine

Fig. 2: Waning HIV-1-specific cellular and humoral immune responses before and after ATI.

From: In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

Fig. 2

a,b, NK cells (a) and CD8+ T cells (b) both showed decreasing and stable immune activation (coexpression of CD38 and HLA-DR). See also data from months 41–59 after HSCT for IciStem no. 19 as published in ref. 8. Data are shown as the mean with s.d. and a reference range from a healthy cohort (n = 8) in gray as the median with interquartile range (IQR). c, HIV-1-specific CD8+ T cell responses (production of IFNγ, TNFα, IL-2 and/or expression of CD107a) against HIV-1 Gag (burgundy), Nef (dark purple) and Pol (light purple) peptide pools waned after HSCT. See also the data from months 39 and 42 after HSCT for IciStem no. 19 as published in ref. 8. The dotted line represents the average background signal. d, Full-virus lysate immunoblot for antibodies against HIV-1 antigens revealed waning HIV-1-specific antibody responses after HSCT and prolonged weakening of gp160- and gp120-specific antibodies. M+, months after HSCT.

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