Extended Data Fig. 3: RELN CTR structural determination.
From: Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man
a, In silico models for the 20 lowest energy structures of CTR-RELN produced by 2D NMR. b, Representative CD spectra of CTR-RELN without heating showing that the CTR-RELN has primarily an alpha helical structure while the peptide without 50% 2, 2, 2-Trifluoroethanol has a spectrum closest to a random coil. Data is presented as the average of four spectra. Secondary structure analysis is reported in Supplementary Table 7.
