Extended Data Fig. 5: V(D)J usage by cell type in I2 PSC. | Nature Medicine

Extended Data Fig. 5: V(D)J usage by cell type in I2 PSC.

From: Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis

Extended Data Fig. 5

a-e, TRBV (a), TRBD (b), TRBJ (c), TRAV (d) and TRAJ (e) gene usage by cell type amongst CD4 T cells from I2 PSC patients. f, Proportion of cells containing amino acid motif ‘LA’ in the TCR beta chain by cell type amongst I2 PSC patients using TRBD2. Gray lines denote paired values from the same patients. SP = ‘single positive’, DP = ‘double positive’ i.e. IL17A+ FOXP3+. Significance determined by two-sided, unpaired Wicoxon text. a-f, Datapoints and box plot color denotes cell type (pink = IL17A+ FOXP3+ DP, orange = IL17A+ SP, blue = FOXP3+ SP, gray = negative for IL17A and FOXP3). n = 3 PSC I2, 1,858 cells. a–e, Center line represents the median value; hinges indicate the 1st and 3rd quartiles; upper and lower whiskers extend to the largest and smallest values that are within 1.5 times the interquartile range from 1st and 3rd quartiles, respectively. Significance test using two-sided, unpaired Wilcoxon test without adjustment for multiple comparisons. No test reached significance (p < 0.05).

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