Extended Data Fig. 6: Expression of key genes in the persisting CAR T-cell signature.
From: Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia
Boxplots show the percent of T cell expression for (a) GZMK, (b) TIGIT, and (c) GPR183 for flow-based immunophenotyping (left) and single-cell RNA sequencing (scRNA-seq) data. CAR-T cell scRNA-seq, data is derived from 60188 cells from 43 independent samples. For non-CAR T-cell scRNAseq, data is derived from 98003 cells from 43 independent samples. Flow data is derived from 15 independent samples. Box plots show the first quartile (the lower end of the box) and the third quartile (the upper other end of the box), as well as the median values (centre line) per dataset. The ‘whiskers’ extend from the ends of the box to a maximum and minimum of 1.5 times the interquartile range beyond the box. Outliers are shown as dots.
