Fig. 3: Cell typing and defining a persisting CAR-T cell transcriptional signature.
From: Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia
a, UMAP of CAT CAR-T cells shows closest cell type matching using a PBMC reference and cell-marker-based annotation. Late (persisting, M7–M60) CAR-T cells are in green hues; mid (M4–6) CAR-T cells are in black/blue hues; and early (M1–3) CAR-T cells are in pink/red hues. b, Stacked bar plots show dynamic cell type proportions over time for a representative patient (P01). The top five abundant cell types in the dataset are shown. c, Contour plots quantify expression of GZMK against GZMH across patients per timepoint. d, Heat map shows differential gene expression results creating gene signatures of each timepoint. DN, double-negative; TCM, central memory; TEM, effector memory.
