Fig. 5: Population structures of CAR-T cells.
From: Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia
a, Representative sample (P02) illustrating the changes in clonal architecture of CAR-T cells over time. Packed circle plots show the size of each clonotype. Filled-in black circles represent clonotypes that are not unique, as they are observed across timepoints. Conversely, pink donut circles represent clonotypes that are unique to that timepoint (and not observed across time). Blue/purple/gray colored circles represent the dominant clonotype at that timepoint that corresponds with the clonal trajectories below. b, Cell type composition stacked bar plots demonstrate the shift in cell type abundances between early and late timepoints and between unique and non-unique clonotypes. TEM, effector memory.
