Fig. 3: Correlates of long-term responders. | Nature Medicine

Fig. 3: Correlates of long-term responders.

From: Idecabtagene vicleucel for relapsed and refractory multiple myeloma: post hoc 18-month follow-up of a phase 1 trial

Fig. 3

Logistic regression analyses of starting material PBMC and final DP correlates from long-term responders (patients with PFS ≥ 18 months; n = 13) and non-long-term responders (n = 46) and time of recent exposure to selected prior antimyeloma drug classes as a potential correlate of the PBMC and DP variables enriched in long-term responders. Three patients were censored from the total treated population (n = 62) due to study discontinuation before progression (n = 1), start of subsequent antimyeloma therapy before progression (n = 1) and ongoing response with a <18-month progression-free interval (n = 1). Note that the y-axis labels corresponding to the staining patterns defined for each type of cell are shown in the table of median values below the plots. Box plots show nominal P value of the long-term response coefficient from a nonparametric linear regression where rank (Y) ~ long-term response + dose and Y is the rank order value of the PBMC or DP attribute of interest. P values are not corrected for multiple hypothesis testing.

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