Extended Data Fig. 2: Disposition of tumour biopsies assessed for CD8-positive cell quantitation.

a) CONSORT diagram of tumour biopsies assessed for CD8-positive cell quantitation. b) Alluvial plot depicting the patient demographics (x-axis) for each patient (alluvium) that was included in the final analysis for CD8 T-cell quantitation. Demographics include trial arm, best overall response (BOR, also shown by fill colour), whether pathologic features consistent with melanoma regression were observed on-therapy, and which sample timepoints were included in analysis (either screening or on-therapy biopsy only, or paired). c) Alluvial plot depicting patient demographics and pathologic annotation (x-axis) for each biopsy (alluvium) that was annotated by the dermatopathologists. Fill colour indicates whether the biopsy was included in the final analysis for CD8 T cell quantitation. Biopsies are annotated for the trial arm, BOR, and whether features consistent with pathologic regression of melanoma were noted in the on-therapy biopsies for the corresponding patient, as well as the timepoint the biopsy was taken, and the manual notes for the biopsy from the dermatopathologists.