Fig. 3: Integration sites and chromatin features of HIV-1 proviruses.
From: Viral and host mediators of non-suppressible HIV-1 viremia
a, Circos plot showing the location of each integration site across human chromosomes. b, Karyotyping heatmap showing the percentage of integration sites in each human chromosome for different classes of proviruses. Fisher’s exact test was used. c, Number of peaks for key histone marks in 10-kb regions flanking the proviral integration sites. Center lines represent medians. We used Tukey boxplots, in which boxes represent median values and first–third quartiles. Two-sided Kruskal–Wallis test was used to evaluate if there was significant differences among three groups and if so, two-sided Mann–Whitney U test was used to compare between-group differences. d, Correlation between enrichment of H3K36me3 histone marks near producer proviral integration sites and plasma clone viral loads (viral load multiplied by fraction of plasma sequences matching the producer provirus). Host gene integration sites are labeled. Two-sided Spearman correlation test was used. VL, viral load.
