Fig. 4: Transcriptomic analysis of CD4+ T cells from participants with NSV.
From: Viral and host mediators of non-suppressible HIV-1 viremia
a, Volcano plot shows DEGs in participants with NSV versus ART-suppressed individuals. Red and blue colors highlight differential statistical significance. Adjustments were made for multiple comparisons using the Benjamini–Hochberg method built in the DESeq2 package. b, Normalized enrichment score (NES) reflects the degree to which a set of genes is overrepresented among genes that are differentially expressed between participants with NSV and ART-suppressed control participants. Bar plot represents positively (red) and negatively (blue) correlated pathways. Adjustments were made for multiple comparisons using the Benjamini–Hochberg method. c, Genes related to apoptosis/cell death enriched in participants with NSV. d, Comparison of anti-apoptotic and pro-apoptotic gene transcription levels between NSV and ART-suppressed control group. Two-sided Mann–Whitney U tests were used for comparisons. TPM, transcripts per million.
