Fig. 4: Somatic and germline alterations across common tumor types. | Nature Medicine

Fig. 4: Somatic and germline alterations across common tumor types.

From: Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme

Fig. 4

Prevalence of different types of mutations identified using WGS in genes indicated for testing in the NGTDC. The leftmost panel indicates the total percentage of cases harboring one or more genomic alterations of clinical relevance as listed in the NGTDC (where the number of cancers sequenced is ten or more). In the subsequent panels, somatic variants (from left to right) consisting of small variants (SNVs, indels), CNAs, SVs, HRD, MMR signatures and TMB along with germline variants related to inherited cancer risk (predisposing genes) and pharmacogenomic (PGx) findings (toxicity-associated DPYD variants) are shown. The top five genes with the most prevalent mutation rates for each mutation type are shown (see Extended Data Fig. 1 for the full analysis). The percentage of tumors harboring a specific type of mutation in the gene(s) indicated for testing according to tumor type in the NGTDC are shown in magenta. Mutation incidence (as a percentage) in other tumor types, not currently indicated in the NGTDC, is shown in blue. Color gradation reflects the percentage of affected cases.

Back to article page