Fig. 6: Prognostic value of small variants and CNAs from WGS data. | Nature Medicine

Fig. 6: Prognostic value of small variants and CNAs from WGS data.

From: Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme

Fig. 6

a, Co-occurrence of CNAs and small variants in clinically actionable genes. The bars represent the proportion of cases with CNA in the subset of cases with or without small variants (SNV or small indels) in clinically actionable genes. Oncogenes and tumor suppressor genes were tested for gain (red) or loss (blue) of at least one copy of the corresponding gene, respectively. b, Kaplan–Meier estimates of overall survival with P values calculated using a stratified log-rank test. The numbers of patients at risk at different time points are indicated below the survival curves. Points and error bars on the embedded forest plots indicate HRs with 95% CIs, correspondingly. HRs, CIs and P values were calculated from Cox proportional-hazards models corrected according to cancer stage. Patients were stratified according to the mutational status of genes indicated for testing in NGTDC across all cancer types (n = 11,337). Exact P values can be found in Supplementary Table 2.

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