Fig. 5: A balance predictive of ICB-induced colitis at baseline.
From: Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma
A balance between the 10 SGBs associated with the presence of colitis (red; n = 24 patients) and the 12 SGBs associated with the absence of colitis (blue; n = 112 patients) at baseline is predictive of colitis development at baseline. Left: the balance’s discriminatory ability (two-sided Wilcoxon test, PT0 = 0.00055). Boxplots represent minima, Q1, Q2, Q3 and maxima. Right: the same balance’s predictive ability expressed as the averaged AUC computed from a 100 times repeated five-fold cross-validation (AUC mean ± s.d. of 0.723 ± 0.121). The dashed diagonal line represents random chance.
