Table 1 Demographic and baseline characteristics (safety population)
SOC | GSK3036656 (ganfeborole) | ||||
|---|---|---|---|---|---|
Characteristic | N = 18 | 1 mg | 5 mg | 15 mg | 30 mg |
N = 9 | N = 17 | N = 16 | N = 15 | ||
Male sex, n (%) | 18 (100) | 9 (100) | 17 (100) | 16 (100) | 15 (100) |
Age (years), mean (s.d.) | 37.0 (10.20) | 37.8 (8.38) | 38.1 (10.33) | 39.8 (12.33) | 38.5 (9.82) |
Race, n (%) | |||||
Black | 18 (100) | 9 (100) | 17 (100) | 16 (100) | 15 (100) |
Height (cm), mean (s.d.) | 172.9 (4.85) | 169.6 (4.07) | 169.9 (7.71) | 172.8 (5.81) | 170.7 (5.60) |
Weight (kg), mean (s.d.) | 55.22 (6.410) | 51.36 (4.085) | 53.24 (6.235) | 58.49 (10.457) | 53.21 (6.376) |
BMI (kg/m²), mean (s.d.) | 18.46 (1.861) | 17.87 (1.399) | 18.44 (1.727) | 19.55 (2.956) | 18.27 (2.099) |
Cigarettes per day | 16 | 9 | 15 | 14 | 12 |
n (%) | |||||
<20 | 15 (94) | 7 (78) | 13 (87) | 10 (71) | 12 (100) |
≥20 | 1 (6) | 2 (22) | 2 (13) | 4 (29) | 0 |
HIV positive, n (%) | 0 | 0 | 0 | 2 (13) | 0 |
Baseline CFU (log10CFU) (efficacy population) | |||||
n | 17 | 9 | 17 | 16 | 14 |
Mean (s.d.) | 6.28 (0.736) | 6.30 (1.485) | 5.95 (0.949) | 5.94 (0.810) | 5.97 (1.498) |
Baseline TTP (h) (efficacy population) | |||||
Mean (s.d.) | 107.74 (34.979) | 120.03 (53.002) | 112.28 (27.885) | 95.63 (21.615) | 119.85 (42.229) |
