Extended Data Fig. 8: Post-hoc analyses correlating DST results with clinical outcomes. | Nature Medicine

Extended Data Fig. 8: Post-hoc analyses correlating DST results with clinical outcomes.

From: Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers

Extended Data Fig. 8

(a) Plot of the relationship between PFS and DSS of associated treatments in FPM-guided patients. P value is from two-sided Spearman correlation of DSS and PFS. Blue dashed line represents a line of simple linear regression. (b) Distribution of DSS separated by response type (left) and response class (NR = Non-Responder, R = Responder) in patients reviewed by the FPMTB. P value is from two-sided Mann-Whitney U test comparing DSS in R and NR classes. CR = complete response, PR = partial response, SD = stable disease, PD = progressive disease. Data are presented as mean values with individual points. In the left panel, PD represents n = 6 patients, SD represents n = 1 patient, PR represents n = 2 patients, CR represents n = 4 patients. In the right panel, NR represents n = 7 patients, R represents n = 6 patients. ^ indicates n = 4 points are at 0. (c) Receiver operating characteristic (ROC) curve of true positive rate and false positive rate of DSS-based response prediction. d) Confusion matrix and associated statistical values of DSS predicted and actual OR in FPM-guided patients and TPC patients at optimal threshold (DSS > 25). Prediction performance metrics (Accuracy, Precision/Positive Predictive Value, Negative Predictive Value, Recall, MCC, F1) are provided below the confusion matrix.

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