Fig. 5: Comparative analyses of the breast tissues of women of African ancestry with women of European ancestry using snRNA-seq. | Nature Medicine

Fig. 5: Comparative analyses of the breast tissues of women of African ancestry with women of European ancestry using snRNA-seq.

From: Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry

Fig. 5

a, Fibroblasts and epithelial cells of the breast tissue cluster were different in women of African ancestry compared to women of European ancestry. b, ESR1 and FOXA1 expression patterns in epithelial cell clusters of women of African and European ancestry. As with the multiome data, FOXA1 expression was restricted to LHS cells and ESR1 expression was higher in LHS cells compared to LASP cells in both groups. c, MKI67 expression patterns in the breast tissues of women of African and European ancestry. d, PROCR, ZEB1 and PDGFRα expression patterns in the breast tissues of women of African and European ancestry. e, Fibroblasts in women of African and European ancestry showed distinct cell states. f, The fibro-prematrix state was dominant in African ancestry, while the fibro-matrix state was more prominent in European ancestry. g, Genetic ancestry-dependent and germline mutation-dependent variability in the clustering of fibroblasts.

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