Extended Data Fig. 2: Dotplot of immune cell populations during treatment, determined by flow cytometry.

Populations were defined as shown in Supplementary Material Fig. 1. Parent population are indicated in parentheses. The ratio of each population was calculated as current visit/baseline for each participant for every timepoint for which they had data. Statistical significance was determined using a two-sided Wilcoxon test and circle size is scaled by p value, with more significant p values represented by larger circles. Data points with p < 0.05 are coloured by the median ratio of population size (grey=1 (unchanged) to purple 0.5 (halved) and green 1.5 (increased by 50%)). Data points with p > 0.05 are coloured white.