Table 1 Demographics for fMRI and EEG datasets

From: Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

 

HC

MCI

AD

bvFTD

Statistics non-LAC versus LAC

Post hoc comparisons

Full dataset

All participants (N = 5,306)

n = 3,509

n = 517 

n = 828

n = 463

  

fMRI dataset

Variable

Non-LAC: n = 967; LAC: n = 477

Non-LAC: n = 215; LAC: n = 169

Non-LAC: n = 214; LAC: n = 505

Non-LAC: n = 190; LAC n = 216

  

Sex (female:male)

Non-LAC

470:497

114:101

112:102

98:92

χ2 = 2.19

P = 0.533

HC-MCI: P = 0.453

HC-AD: P = 0.462

HC-bvFTD: =0.472

LAC

261:216

84:85

262:243

105:111

χ2 = 2.76

P = 0.429

HC-MCI: P = 0.438

HC-AD: P = 0.447

HC-bvFTD: P = 0.459

Age (years) (range: 22–91)

Non-LAC

53.55 (13.43)

59.62 (8.77)

76.59 (9.35)

73.14 (8.56)

F = 3.13

P = 0.47

ηp2 = 0.02

HC-MCI: P = 0.443

HC-AD: P = 0.451

HC-bvFTD: P = 0.461

LAC

65.34 (11.44)

66.53 (8.18)

77.52 (9.35)

73.15 (8.76)

F = 3.62

P = 0.45

ηp2 = 0.02

HC-MCI: P = 0.39

HC-AD: P = 0.41

HC-bvFTD: P = 0.461

Years of education (range: 0–25)

Non-LAC

13.15 (5.41)

14.15 (3.41)

13.12 (5.34)

11.16 (3.56)

F = 2.19

P = 0.49

ηp2 = 0.02

HC-MCI: P = 0.472

HC-AD: P = 0.484

HC-bvFTD: P = 0.491

LAC

12.11 (3.39)

11.52 (6.32)

8.89 (4.34)

7.89 (3.36)

F = 1.31

P = 0.68

ηp2 = 0.01

HC-MCI: P = 0.672

HC-AD: P = 0.681

HC-bvFTD: P = 0.654

EEG dataset

  

Non-LAC n = 569; LAC n = 1,486

LAC n = 133

LAC n = 108

LAC n = 57

  

Sex (female:male)

Non-LAC

470:99

—

—

—

χ2 = 64.62

P = 1 × 10−15

—

 

LAC

954:532

111:22

85:23

39:18

χ2 = 28.05

P = 0.000003

HC-MCI: P = 0.063

HC-AD: P = 0.071

HC-bvFTD: P = 0.075

Age (years) (range: 21–92)

Non-LAC

58.98 (12.03)

—

—

—

t = 4.21

P = 0.07

ηp2 = 0.02

—

LAC

66.74 (13.94)

62.54 (9.98)

78.62 (8.34)

71.05 (9.34)

F = 7.62

P = 0.0005

ηp2 = 0.07

HC-MCI: P = 0.052

HC-AD: P = 0.061

HC-bvFTD: P = 0.067

Years of education (range: 0–24)

Non-LAC

14.85 (4.91)

—

—

—

t = 3.54

P = 0.08

ηp2 = 0.01

—

LAC

13.92 (3.39)

8.12 (4.34)

10.75 (6.32)

14.38 (5.49)

F = 6.31

P = 0.0007

ηp2 = 0.06

HC-MCI: P = 0.058

HC-AD: P = 0.063

HC-bvFTD: P = 0.069

  1. Results are presented as mean (s.d.). Demographic data comparing non-LAC and LAC groups were assessed using unpaired two-sided t-tests, whereas data for pathological groups were analyzed using right-sided analyses of variance followed by Tukey post-hoc pairwise comparisons, except for sex, which was analyzed using two-sided Pearson’s chi-squared (χ²) test. Effect sizes were calculated using partial eta squared (ηp²). AD, Alzheimer disease; F, F-statistic from ANOVA; t, t-statistic from t-test.
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