Extended Data Fig. 3: Concentration-response curves of glioblastoma cell lines.
a-d, Concentration-response curves of glioblastoma cell lines (a, LN-229; b, LN-308; c, ZH-161; d, ZH-562) for a subset of neuroactive drugs (n = 9 drugs) across different concentrations (logarithmically spaced x-axis, n = 5 concentrations). a, b, Y-axis denotes relative cell counts or c, d, relative 2D-projected spheroid area for 3D cultures normalized to DMSO control. Concentration-response curves (solid black lines) are fitted when possible with a two-parameter log-logistic distribution with 95% confidence intervals (shaded per cell line) and ED50 (red dashed lines). n = 3-5 replicate wells/drug (dots), n = 15 DMSO wells.
