Extended Data Fig. 4: ctDNA status in the MRD and surveillance windows is predictive of post-recurrence survival among patients who recurred.
From: ctDNA-based molecular residual disease and survival in resectable colorectal cancer
a-b. Kaplan-Meier estimates for PRS stratified by ctDNA status during the MRD window (a) or surveillance window (b) among patients with CRC who had radiological recurrence during follow-up. Hazard ratios (HRs) and 95% CIs were calculated using the Cox proportional hazard model. P values were calculated using the two-sided log-rank test. All analyses were landmarked at the date of radiological recurrence. Median PRS and percent PRS at 24 months were estimated from the landmark time point. c. Bar plot demonstrating the proportion of ctDNA-negative (N = 90) and ctDNA-positive (N = 79) patients undergoing curative resection for recurrence lesions. Error bars represent 95% confidence intervals. P value was generated based on the two-sided Chi-square test. Abbreviations: MRD, molecular residual disease; PRS, post-recurrence survival.
