Fig. 1: Timeframe for analysis for PASADENA and PPMI.

In PASADENA, the delayed-start group received placebo during the first year of the trial (light gray bar), after which they were switched to prasinezumab (light blue bar). The early-start group (dark blue bar) received prasinezumab for the whole duration of the trial. The PPMI study (dark gray bar) received no intervention.