Extended Data Fig. 7: Association of pPS with age at type 2 diabetes diagnosis, stratified by sex and ancestry.
From: Genetic basis of early onset and progression of type 2 diabetes in South Asians
Sex- and ancestry-stratified associations between 12 partitioned polygenic scores (pPS), a type 2 diabetes polygenic risk score (T2D PRS), and age at diagnosis of type 2 diabetes, in 9771 male (Blue line) and female (red line) Pakistani (bottom row) and Bangladeshi (top row) individuals with type 2 diabetes in the Genes & Health study. Sex- and ancestry-specific lines of best fit with 95% confidence intervals are plotted for each pPS, with male and female betas estimated from univariate logistic regression models regressing age at diagnosis on each pPS presented in each panel heading.
