Extended Data Fig. 3: Association of pPS with metabolic traits at the time of type 2 diabetes diagnosis.
From: Genetic basis of early onset and progression of type 2 diabetes in South Asians
Association between 12 diabetes partitioned polygenic scores (pPS) and z-normalised diabetes-related traits at the time of diagnosis in 9771 south Asian individuals with a diagnosis of type 2 diabetes. Data are presented as spider plots for each pPS, showing beta per standard deviation of pPS; the minimum value on each trait axis (comparable between pPS) represents the lowest beta for any pPS for that trait; the maximum value represents the highest beta for any pPS for that trait. EG, BMI and Waist circumference are highest in the ‘Obesity’ pPS; ALP is lowest in the ‘ALP Neg’ pPS. To allow comparison between traits, all traits were z-scored to a normal distribution with mean and median of 0 and standard deviation of 1. Only trait values within 1 year of diagnosis were included in analysis; where more than one trait was present, the value closest to time of diagnosis was used. ALP - alkaline phosphatase (n = 7422). ALT - alanine transferase (n = 7631). BMI - body mass index (n = 5791). HDL - high density lipoprotein (n = 7304). LDL = low density lipoprotein (n = 6365). RPG - random plasma glucose(n = 3777). FPG - fasting plasma glucose (n = 4786). Trigs - serum triglycerides (n = 6357). Waist - waist circumference (n = 1922). HbA1c = glycated haemoblogin (n = 7326).
