Fig. 4: Change in LC symptoms as secondary outcomes at 6 months.

a–f, Physical (a) and mental (b) fatigue; HADS anxiety (c) and depression (d); quality of life (EQ-5D visual scale (e) and utility (f)); systolic (g) and diastolic (h) blood pressure. The data are presented as means, with the shaded areas representing the 95% CIs. Two-sided P values (linear regression) represent the treatment effect compared with baseline: at 3 months for physical fatigue (P < 0.0001, n = 217), mental fatigue, (P < 0.0001, n = 217), HADS anxiety (P = 0.0167, n = 217), HADS depression, (P < 0.0001, n = 217), EQ-5D visual scale (P = 0.0023, n = 217), EQ-5D utility (P = 0.0041, n = 217), SBP (P < 0.0001, n = 216), DBP (P = 0.0378, n = 216) at 6 months for physical fatigue (P < 0.0001, n = 214), mental fatigue, (P = 0.0032, n = 214), HADS anxiety (P = 0.2947, n = 214), HADS depression, (P = 0.0052, n = 214), EQ-5D visual scale (P = 0.0019, n = 214), EQ-5D utility (P = 0.0725, n = 214), SBP (P = 0.0126, n = 212), DBP (P = 0.0160, n = 212). No adjustment is made for multiple comparisons.