Extended Data Fig. 2: Difference in treatment effect based on age, deprivation level (IMD), baseline body mass index (BMI), sex, primary symptom selected (and whether this included fatigue or not).

Data are presented as means with 95% confidence intervals. Two-sided p-values represent the interaction between subgroup and treatment (linear regression/ANCOVA), exploring age ( < 42.1: n = 71, 42.2 to 51.4: n = 69, >51.4: n = 74, p = 0.5750), IMD (1st to 5th decile: n = 86, 6th to 10th decile: n = 128, p = 0.3191), BMI (Below 30: n = 31, 30 or above: n = 183, p = 0.0861), sex (female: n = 182, male: n = 31, p = 0.2255), primary symptom selected (Pain: n = 26, Breathlessness: n = 35, Fatigue: n = 115, Other: n = 37, p = 0.6053), and fatigue as a primary symptom (Yes: n = 115, No: n = 99, p = 0.3696).