Table 2 Summary of primary and secondary outcome measures

From: Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial

 

Single or triple infusion

Control

Difference in change

Baseline (n = 27)

90 d (n = 26)

Baseline to 90-d change (n = 26)

Baseline (n = 24)

90 d (n = 24)

Baseline to 90-d change (n = 24)

    

Mean

s.d.

Mean

s.d.

Mean

s.d.

Mean

s.d.

Mean

s.d.

Mean

s.d.

Mean

95% CI

P

Test

MELD

11.89

1.77

11.43

2.00

−0.48

1.10

12.00

1.79

12.40

3.15

0.39

1.94

−0.87

(−1.79, 0.04)

0.0601

Unequal

UKELD

50.97

2.05

50.61

2.34

−0.39

2.49

50.93

1.90

50.84

2.13

−0.09

1.97

−0.30

(−1.58, 0.98)

0.639

Equal

Albumin

34.19

3.97

33.96

3.67

−0.38

2.42

31.54

5.17

34.61

3.13

−0.17

2.33

0.62

(−0.71, 1.95)

0.33

Equal

ALT

33.59

16.13

33.00

17.63

−1.12

9.51

37.67

27.34

34.17

26.3

−3.5

7.58

2.38

(−2.53, 7.30)

0.33

Equal

Bilirubin

33.85

13.79

31.88

14.99

−2.15

8.69

36.08

14.47

35.13

16.08

−0.96

7.90

−1.20

(−5.93, 3.54)

0.6141

Equal

INR

1.30

0.15

1.26

0.15

−0.03

0.07

1.22

0.17

1.24

0.20

0.02

0.08

  

0.0861

Fisherʼs exact

Creatinine

72.59

18.59

72.58

20.59

0.19

6.94

83.88

25.10

92.46

47.38

8.58

34.12

8.39

(5.86, 10.92)

0.2255

Equal

ELF

11.55

1.07

11.72

0.90

0.27

0.88

12.33

0.99

12.24

1.43

−0.09

1.22

0.36

(−0.24, 0.96)

0.2328

Equal

VCTE

34.12

15.43

38.51 (n = 19)

18.84

5.97 (n = 19)

17.82

40.62 (n = 18)

18.29

31.46

15.18

−7.73

9.69

13.69

(3.97, 23.42)

0.0074

Unequal

C3M

15.60

4.89

15.37 (n = 25)

5.32

−0.53 (n = 25)

3.26

17.10 (n = 23)

7.92

17.11

7.66

0.15 (n = 23)

4.37

−0.68

(−2.90, 1.55)

0.5444

Equal

Pro-C3

29.53

14.83

24.78 (n = 25)

10.92

−3.82 (n = 25)

8.40

36.35 (n = 23)

20.47

33.23

21.67

−3.99 (n = 23)

7.51

0.17

(−4.48, 4.81)

0.9426

Equal

  1. Data are included for all patients (single and triple infusions) versus controls. Significance was computed using two-sided, two-sample t-tests, controlling for equal variance as indicated. Significance for INR was computed using two-sided Fisher’s exact test. ALT, alanine aminotransferase.
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