Fig. 4: Whole kidney H-scan imaging correlates with post-transplant renal function.
From: A first-in-human study of quantitative ultrasound to assess transplant kidney fibrosis
a, Average eGFR values at 9–12 months post-transplant for LD and DD kidney transplant recipients. b, eGFR values at 9–12 months post-transplant for KDPI ≤ 85% and KDPI > 85% kidneys. c–f, Mean eGFR values at 9–12 months post-transplant, organized by quartiles (Q1–Q4) of whole-kidney H-scan renal fibrosis measurements (c), biopsy site cortex PSR staining (d), percentage of glomeruli with global glomerulosclerosis (e) and biopsy site cortex H-scan renal fibrosis measurements (f). Data presented as mean ± s.e. a,b, A two-tailed Student’s t-test was used. An independent samples t-test comparison for LD versus DD patient eGFR yielded the following test statistics: P = 0.0086, F = 3.07, 95% CI [−1.47, 21.64], η = 0.10; comparison of KDPI yielded the following statistics: P = 0.033, F = 5.15, 95% CI [2.34, 52.44], η = 0.20. c–f, One-way ANOVA with post hoc Tukey’s honestly significant difference analysis was performed, with Bonferroni-corrected significance and testing for effect size. For whole-kidney H-scan, ANOVA statistical results are: F(3, 52) = 7.36, P = 3.63 × 10−4, η = 0.31, Q1 versus Q2 P = 0.0070, Q1 versus Q3 P = 0.025, Q1 versus Q4 P = 0.0016, Q2 versus Q3 P = 0.0071, Q2 versus Q4 P = 0.0019, Q3 versus Q4 P = 0.015. For biopsy site PSR, ANOVA statistical results are: F(3, 52) = 1.44, P = 0.24, η = 0.081, Q1 versus Q2 P = 0.47, Q1 versus Q3 P = 0.99, Q1 versus Q4 P = 1.00, Q2 versus Q3 P = 0.35, Q2 versus Q4 P = 0.85, Q3 versus Q4 P = 1.00. For biopsy site GS, ANOVA statistical results are: F(3, 52) = 1.15, P = 0.34, η = 0.066, Q1 versus Q2 P = 0.49, Q1 versus Q3 P = 1.00, Q1 versus Q4 P = 0.55, Q2 versus Q3 P = 0.75, Q2 versus Q4 P = 1.00, Q3 versus Q4 P = 0.72. For biopsy site H-scan, ANOVA statistical results are: F(3, 52) = 0.71, P = 0.55, η = 0.042, Q1 versus Q2 P = 0.73, Q1 versus Q3 P = 0.94, Q1 versus Q4 P = 0.99, Q2 versus Q3 P = 0.96, Q2 versus Q4 P = 0.57, Q3 versus Q4 P = 0.81. *P < 0.05. c–f created with BioRender.com.
