Extended Data Table 2 Longitudinal volumetric data

From: Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis

  1. Table showing longitudinal volumetric outcomes (normalized to ICV) for HDGE participants compared to controls. Volumetric analyses for brain structure longitudinal changes, excluding the putamen, modeled a single change measure per paired participant scans (boundary-shift integral or voxel-based morphometry convolution) after conversion to annual change rates. These changes were modeled by ordinary least squares regression. Putamen changes were derived from subtraction of baseline and follow-up MALP-EM segmentations divided by follow-up length. Analysis results and residual adjustments reflect control for baseline age, sex, and their interaction. Statistical two-sided group comparisons were adjusted for multiple comparisons using the FDR, with P values, degrees of freedom, and confidence limits provided in the table. Significant values at FDR < 0.15 are highlighted in bold. CL, confidence limit; Df, degrees of freedom; FDR, false discovery rate; HDGE, HD gene expanded; ICV, intracranial volume.
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