Extended Data Table 3 Longitudinal diffusion data

From: Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis

  1. Diffusion (AD, FA, MD, and RD) and NODDI (FWF, ODI, and NDI) metrics were derived for the following regions of interest: corpus callosum (genu, mid and splenium), internal capsule (anterior and posterior) and external capsule. Longitudinal change was derived by subtraction of baseline from follow-up value and change was annualized. Analysis results and residual adjustments reflect control for baseline age, sex and their interaction. Statistical two-sided group comparisons were adjusted for multiple comparisons using the FDR, with P values, degrees of freedom, and confidence limits provided in the table. Significant values at FDR < 0.15 are highlighted in bold. AD, axial diffusivity; CL, confidence limit; Df, degrees of freedom; FA, fractional anisotropy; FWF, free water fraction; HDGE, HD gene expanded; MD, mean diffusivity; NDI, neurite density index; ODI, orientation dispersion index; RD, radial diffusivity.
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