Table 1 Baseline clinical patient characteristics

From: Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial

 

Control (n = 9)

Treated (n = 9)

Age at diagnosis (years)

50.0 (32.0, 68.0)

51.0 (42.0, 83.0)

Age at enrollment (years)

55.0 (35.0, 83.0)

59.0 (43.0, 83.0)

ER (%)

90.0 (0.0, 100.0)

90.0 (0.0, 100.0)

PR (%)

50.0 (0.0, 95.0)

0.0 (0.0, 80.0)

HER2 amplification

3 (33.3%)

0 (0.0%)

Ki67 (%)

37.5 (10.0, 50.0)

37.5 (7.5, 80.0)

Histology

 Ductal

7 (77.8%)

6 (66.7%)

 Lobular

1 (11.1%)

3 (33.3%)

 Mucinous/neuroendocrine

1 (11.1%)

0 (0.0%)

Metastasis sites

 Liver

6 (66.7%)

5 (55.6%)

 Lung

5 (55.6%)

3 (33.3%)

 Bone

7 (77.8%)

9 (100.0%)

 Others

7 (77.8%)

8 (88.9%)

Number of previous treatment lines

2.0 (1.0, 5.0)

1.0 (0.0, 9.0)

  1. The table presents the age (years) at primary diagnosis, age (years) at CTC enumeration, subtype of most recent biopsy (percentage of estrogen receptor (ER)-positive cells, percentage of progesterone receptor (PR)-positive cells, percentage of Ki67-positive cells and HER2 amplification status), histologic subtype (ductal, lobular and mucinous/neuroendocrine), site of metastasis and number of previous systemic treatment lines in nonrandomized cohorts of control and digoxin-treated patients. The values in the table represent the median (range) for numeric variables and counts (percentage) for categorical variables.