Extended Data Fig. 9: Variant allele frequency in scRNA-seq samples. | Nature Medicine

Extended Data Fig. 9: Variant allele frequency in scRNA-seq samples.

From: Multiomic profiling of T cell lymphoma after therapy with anti-BCMA CAR T cells and GPRC5D-directed bispecific antibody

Extended Data Fig. 9

Single-cell RNA-Seq data was analyzed for reads supporting the TET2 p.R544* variant. Samples of BM-preDexa, PB-preDexa, and PB-postDexa were merged and split into Clone 1_3, Clone 2 and other T-cells (Other clones). For the analysis of the apheresis sample no filtering for T-cells was performed. The frequency of supporting reads is shown for Clone 1_3, Clone 2, other clones and the apheresis sample. For each sample, the number of high-quality supporting reads / total reads is presented. Notably, 3 out of 109 total reads of the TET2 showed the respective variant in the apheresis sample, indicating CHIP origin of this mutation.

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