Fig. 2: Kaplan–Meier analysis of the primary endpoint.

a–d, Kaplan–Meier estimates of freedom from the primary endpoint, which is freedom from documented AF more than 30 s after a single procedure, with or without the use of antiarrhythmic medications after the 3-month blanking period. Comparisons of the tailored arm versus the anatomical arm were performed using the two-sided log-rank test. a, All patients in the mITT population (HR, 0.34; 95% CI, 0.21–0.57). b, All patients in the PP population (HR, 0.29; 95% CI, 0.16–0.51). c, Patients with persistent AF with a duration of AF of 6 months or more in the mITT population (HR, 0.29; 95% CI, 0.15–0.55). d, Patients with persistent AF with a duration of AF greater or equal to 6 months in the PP population (HR, 0.18; 95% CI, 0.08–0.40). In a–d, P < 0.0001 for all comparisons between the tailored and anatomical arms.