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Cities, communities and clinics can be testbeds for human exposome and aging research

Understanding the human exposome is now possible with clinics, communities and cities acting as real-world testbeds to understand what drives human healthspan, resilience and flourishing.

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Fig. 1: Functional exposomics approach to study the exposome.

References

  1. Vrijheid, M. Thorax 69, 876–878 (2014).

    Article  PubMed  Google Scholar 

  2. Furman, D. et al. Nat. Med. 25, 1822–1832 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Minnis, H. et al. Nat. Mental Health 2, 132–140 (2024).

    Article  Google Scholar 

  4. Kern, C. et al. Preprints at Preprints.org https://www.preprints.org/manuscript/202310.1387/v4 (2024).

  5. Moqri, M. et al. Cell 186, 3758–3775 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ren, J. et al. Nat. Med. 29, 2162–2165 (2023).

    Article  CAS  PubMed  Google Scholar 

  7. Abdelzaher, H. et al. Front. Public Health 10, 973000 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Fayet, Y., Bonnin, T., Canali, S. & Giroux, E. Soc. Sci. Med. 354, 117056 (2024).

    Article  PubMed  Google Scholar 

  9. Lin, X. et al. Biosensors 12, 1131 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Lu, J. K., Wang, W., Goh, J. & Maier, A. B. Heliyon 10, e33488 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Bedia, C. Trends Environ. Anal. Chem. 34, e00161 (2022).

    Article  CAS  Google Scholar 

  12. Stenvinkel, P., Shiels, P. G. & Johnson, R. J. J. Environ. Manage. 328, 116981 (2023).

    Article  CAS  PubMed  Google Scholar 

  13. National Innovation Centre for Ageing. City of Longevity brochure https://go.nature.com/4gnnVn6 (2023).

  14. Giuffrè, M. & Shung, D. L. npj Digit. Med. 6, 186 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Zhang, P. et al. Environ. Sci. Technol. Lett. 8, 839–852 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Tina Woods or David Furman.

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T.W. is paid for her part-time roles as ‘healthy longevity champion’ for the National Innovation Centre for Ageing and executive director of the International Institute of Longevity. Other authors declare no competing interests.

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Woods, T., Palmarini, N., Corner, L. et al. Cities, communities and clinics can be testbeds for human exposome and aging research. Nat Med 31, 1066–1068 (2025). https://doi.org/10.1038/s41591-025-03519-8

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