Understanding the human exposome is now possible with clinics, communities and cities acting as real-world testbeds to understand what drives human healthspan, resilience and flourishing.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout

References
Vrijheid, M. Thorax 69, 876–878 (2014).
Furman, D. et al. Nat. Med. 25, 1822–1832 (2019).
Minnis, H. et al. Nat. Mental Health 2, 132–140 (2024).
Kern, C. et al. Preprints at Preprints.org https://www.preprints.org/manuscript/202310.1387/v4 (2024).
Moqri, M. et al. Cell 186, 3758–3775 (2023).
Ren, J. et al. Nat. Med. 29, 2162–2165 (2023).
Abdelzaher, H. et al. Front. Public Health 10, 973000 (2022).
Fayet, Y., Bonnin, T., Canali, S. & Giroux, E. Soc. Sci. Med. 354, 117056 (2024).
Lin, X. et al. Biosensors 12, 1131 (2022).
Lu, J. K., Wang, W., Goh, J. & Maier, A. B. Heliyon 10, e33488 (2024).
Bedia, C. Trends Environ. Anal. Chem. 34, e00161 (2022).
Stenvinkel, P., Shiels, P. G. & Johnson, R. J. J. Environ. Manage. 328, 116981 (2023).
National Innovation Centre for Ageing. City of Longevity brochure https://go.nature.com/4gnnVn6 (2023).
Giuffrè, M. & Shung, D. L. npj Digit. Med. 6, 186 (2023).
Zhang, P. et al. Environ. Sci. Technol. Lett. 8, 839–852 (2021).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
T.W. is paid for her part-time roles as ‘healthy longevity champion’ for the National Innovation Centre for Ageing and executive director of the International Institute of Longevity. Other authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Woods, T., Palmarini, N., Corner, L. et al. Cities, communities and clinics can be testbeds for human exposome and aging research. Nat Med 31, 1066–1068 (2025). https://doi.org/10.1038/s41591-025-03519-8
Published:
Issue date:
DOI: https://doi.org/10.1038/s41591-025-03519-8