Extended Data Fig. 6: Association of plasma biomarkers and Aβ-PET in the validation cohort.

Only Aβ-positive individuals (a) and all individuals (b) with available data are included in the scatter plots. Dots are gray-color-coded to indicate tau-PET negativity in the Global (Braak I-VI) regions of interests (ROI) while other color-coded dots indicate tau-PET positivity. MAPT R406W mutation carriers are shown in pink. Plasma thresholds were derived using Gaussian mixture modelling. We used previously validated cutoffs for Aβ-PET (SUVR > 1.03). Tau-status was assessed using global tau-PET (SUVR > 1.22). The percentage of individuals in each of the four quadrants is displayed. Standardized β values from linear regression analyses, adjusted for age and sex, are also shown. LOESS trend lines (solid black) with 95% confidence intervals (shaded area) illustrate data tendencies. All tests were two-sided and all p-values < 0.001. ***p:<0.001. Abbreviations: LOESS, locally estimated scatterplot smoothing; SUVR, standardized uptake value ratio.