Fig. 2: Association of plasma tau biomarkers with tau-PET in the validation cohort.
From: Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease
a–c, Plots including only tau-PET-positive individuals (a, n = 172), Aβ-positive individuals (b, n = 436) and all participants (c, n = 649). Plasma thresholds were derived using Gaussian mixture modeling. We used previously validated cutoffs for global tau-PET (SUVR > 1.22). Dots are gray color coded to indicate the global tau-PET negativity whereas other color-coded dots indicate tau-PET positivity. MAPT R406W mutation carriers are shown in pink outline. The percentage of individuals in each of the four quadrants is displayed. Standardized β values from linear regression analyses, adjusted for age and sex, are also shown. Locally estimated scatterplot smoothing trend lines (solid black) with 95% CIs (shaded area) illustrate data tendencies. All tests were two sided. All P values were <0.001. ***P < 0.001.
