Extended Data Fig. 2: Cross-correlation among plasma biomarkers in the validation cohort. | Nature Medicine

Extended Data Fig. 2: Cross-correlation among plasma biomarkers in the validation cohort.

From: Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease

Extended Data Fig. 2

All individuals with available data are included in these plots. (a) Plasma %p-tau217 vs. eMTBR-tau243, (b) plasma %p-tau205 vs. eMTBR-tau243, and (c) plasma %p-tau217 vs. %p-tau205 are shown. Dots are gray-color-coded to indicate tau-PET negativity in the Global (Braak I-VI) regions of interests (ROI) while white-color-coded dots indicate tau-PET data are not available and other color-coded dots indicate tau-PET positivity. MAPT R406W mutation carriers are shown in pink (one FTD case and one MCI-). Plasma thresholds were derived using Gaussian mixture modelling. Percentage of individuals in each of the four quadrants are shown. Strength of correlation is shown using Spearman’s ρ. All tests were two-sided and all p-values < 0.001. ***p:<0.001. Abbreviations: FTD, frontotemporal dementia; MCI-, mild cognitive impairment without Aβ pathology.

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