Extended Data Fig. 4: Association of plasma biomarkers and tau-PET in different regions in Aβ-positive individuals of the validation cohort.

Association of plasma biomarkers and tau-PET in early region (Braak I-II) (a, n = 436), intermediate region (Braak III-IV) (b, n = 436), and late region (Braak V-VI) (c, n = 436). Only Aβ-positive individuals are included in these plots. Dots are gray-color-coded to indicate tau-PET negativity in the Global (Braak I-VI) regions of interests (ROI) while other color-coded dots indicate tau-PET positivity. MAPT R406W mutation carriers are shown in pink. Plasma thresholds were derived using Gaussian mixture modelling. Tau-status was assessed using global tau-PET with a previously validated cutoff (SUVR > 1.22). The percentage of individuals in each of the four quadrants is displayed. Standardized β values from linear regression analyses, adjusted for age and sex, are also shown. LOESS trend lines (solid black) with 95% confidence intervals (shaded area) illustrate data tendencies. All tests were two-sided and all p-values < 0.001. ***p:<0.001. Abbreviations: LOESS, locally estimated scatterplot smoothing; SUVR, standardized uptake value ratio.