Table 1 Characteristics of participants from the validation cohort
From: Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease
Overall (n = 739) | CU− (n = 110) | CU+ (n = 198) | MCI+ (n = 169) | AD+ (n = 134) | Other (n = 128) | |
|---|---|---|---|---|---|---|
Age, years | 72.4 (9.32) | 63.8 (11.5) | 74.4 (8.41) | 73.8 (7.56) | 75.3 (7.41) | 72.1 (8.14) |
Women, n (%) | 371 (50.2) | 61 (55.5) | 104 (52.5) | 79 (46.7) | 87 (64.9) | 40 (31.3) |
Education, years | 12.8 (3.75) (n = 720) | 13.4 (3.41) (n = 109) | 13.0 (3.65) (n = 197) | 12.7 (4.11) (n = 164) | 12.2 (3.63) (n = 126) | 12.9 (3.78) (n = 124) |
APOE-ε4, n (%) | 388 (52.5) (n = 664) | 43 (39.1) (n = 101) | 93 (47.0) (n = 139) | 122 (72.2) (n = 168) | 95 (70.9) (n = 132) | 35 (27.3) (n = 124) |
Aβ-PET, centiloids | 41.5 (48.3) (n = 483) | −7.26 (5.98) (n = 83) | 48.6 (38.3) (n = 131) | 81.4 (38.9) | 97.9 (36.7) (n = 19) | −1.69 (19.0) (n = 80) |
Aβ positivity, n (%) | 516 (69.8) (n = 732) | 0 (0) | 198 (100) | 169 (100) | 130 (97.0) (n = 130) | 19 (14.8) (n = 125) |
Tau-PET, Braak I–VI (SUVR) | 1.23 (0.321) (n = 649) | 1.08 (0.0757) (n = 104) | 1.13 (0.154) (n = 175) | 1.28 (0.300) (n = 144) | 1.65 (0.471) (n = 105) | 1.09 (0.0826) (n = 121) |
Tau-PET positivity, n (%) | 172 (23.3) (n = 649) | 1 (0.9) (n = 104) | 22 (11.1) (n = 175) | 57 (33.7) (n = 144) | 83 (61.9) (n = 105) | 9 (7.0) (n = 121) |
Plasma eMTBR-tau243 (fmol l−1) | 2.18 (4.64) | 0.0845 (0.0973) | 0.520 (1.06) | 2.32 (3.17) | 8.01 (7.69) | 0.244 (0.587) |
Plasma %p-tau217 (%) | 1.52 (1.24) | 0.460 (0.112) | 1.24 (0.662) | 1.95 (1.06) | 3.07 (1.37) | 0.640 (0.349) |
Plasma %p-tau205 (%) | 0.517 (0.273) | 0.287 (0.133) | 0.437 (0.163) | 0.628 (0.231) | 0.813 (0.293) | 0.383 (0.180) |
MMSE | 26.1 (4.60) (n = 720) | 29.0 (1.37) (n = 108) | 28.8 (1.29) (n = 194) | 26.2 (2.88) (n = 162) | 19.5 (5.43) (n = 129) | 26.1 (3.55) (n = 127) |
