Fig. 1: Schematic illustration of the study design. | Nature Medicine

Fig. 1: Schematic illustration of the study design.

From: Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis

Fig. 1

Left, the brain donor cohort from the NBB included 186 donors. We selected 44 patients with two extreme phenotypes, 26 patients with a very slow disease progression (MSwSP) and 18 patients with a very rapid disease progression (MSwRP), to perform comprehensive histological analyses of a total of 705 MS lesions. BRLs were further characterized using in-depth histological and spatial transcriptomics. Right, the TSPO PET imaging cohort included n = 114 patients with MS with 1,326 lesions in total. Among the 114 patients, 39 patients displayed radiological BRLs (rBRLs). Presence of rBRL was correlated with additional imaging findings and disease progression. ROI, region of interest. DEG, differentially expressed gene. GSEA, gene set enrichment analysis.

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