Extended Data Fig. 8: Imaging findings.
a Examples of T1 and QSM images. Arrows indicate T1 lesions (upper row) and the corresponding sites after QSM analyses (lower row). b-f, There was no difference in lesion volumes, 2–4 mm T1 lesion rim FA values, or core and rim susceptibility values between the individual rBRL lesions and non-rBRL rim-active lesions, but rBRL had significantly lower 2–4 mm T1 lesion rim MD values (Mann-Whitney U-test). g, There was no difference in the presence of iron rims found in individual rBRL and non-rBRL rim-active lesions (Fisher’s exact test). h, Patients with non-rBRL rim-active lesions and progression data from PET imaging onwards available (n = 72): no difference was found in the number of non-rBRL rim-active lesions (Mann-Whitney U-test). i, Patients with rBRL and progression data from PET imaging onwards available (n = 36): there was a trend towards the progressed patients having more rBRL (p = 0.066; Mann-Whitney U-test). Mean follow-up time from PET imaging to follow-up EDSS measurement was 5.5 years (SD 2.3). j-k, Proportion of non-rBRL rim-active lesions (j) and rBRL (k) in an untreated MS cohort (n = 18) followed up clinically for an average of 6.5 (SD 2.4) years from PET imaging (n = 11 with progression, n = 7 remaining stable). l, In reference to Fig. 5x–y, this table shows the baseline lesion phenotype status of the rBRLs detected at follow-up PET imaging at one year time point for the untreated cohort (n = 9).
