Extended Data Fig. 3: Comparison of the histopathological characteristics of MS patients with rapid disease progression (MSwRP) with and without BRL.

a to c, MSwRP with and without BRL had comparable proportions of active and inactive lesions. c, only a small subset of lesions in MSwRP display signs of marked remyelination independent of the presence or absence of BRL; d, No difference in the cortical lesion rate between MSwRP with and without BRL; a to d: violin plots, two-tailed p-values were determined by Mann-Whitney test.