Fig. 5: Responses of prediabetes and T2D-associated metabolites to a 2-week diet intervention or before and after exercise. | Nature Medicine

Fig. 5: Responses of prediabetes and T2D-associated metabolites to a 2-week diet intervention or before and after exercise.

From: Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes

Fig. 5

Heatmap showing the overlapping metabolites involved in amino acid, lipid and xenobiotic metabolism (n = 123) in two clinical trials of either diet (14 days) or exercise for 1-h (before, 120 and 180 min after exercise) interventions with those 502 altered metabolites in prediabetes and T2D. Responses reversed (Y, yes; N, no) by either diet (D) or exercise (E) or both (B) were clustered and are shown in distinct colors beside the row clustering branches. Representative metabolites including 14 overlapping with Fig. 4f are labeled in red, and five others in black. Wilcoxon rank-sum test and one-way repeated-measures analysis of variance were used to identify altered metabolites in the cohorts and two longitudinal datasets (Padj < 0.1), respectively.

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