Extended Data Fig. 3: Simulated concentration-time profile of PRAX-222 in lumbar CSF. | Nature Medicine

Extended Data Fig. 3: Simulated concentration-time profile of PRAX-222 in lumbar CSF.

From: Antisense oligonucleotide treatment in a preterm infant with early-onset SCN2A developmental and epileptic encephalopathy

Extended Data Fig. 3

Simulated median (90% PI) PRAX-222 concentration-time profile in lumbar CSF following IT-L administration of titrated PRAX-222 dose amounts to the single EAP participant overlaid upon the observed data. Conc.: concentration; CSF: cerebrospinal fluid; EAP: Emergency Access Program; IT-L: intrathecal lumbar; LLOQ: lower limit of quantification; PI: prediction interval.

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