Extended Data Fig. 6: Time- and dose-associated changes in serum protein expression associated with rentosertib treatment. | Nature Medicine

Extended Data Fig. 6: Time- and dose-associated changes in serum protein expression associated with rentosertib treatment.

From: A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial

Extended Data Fig. 6

(a) Change in Normalized Protein eXpression (NPX) from baseline to subsequent visits (weeks 4, 8, and 12) with a simple linear regression model (delta_NPX ~ treatment_cat) fitted to assess the relationship between treatment dose and protein expression changes using Benjamini-Hochberg (BH)-adjusted P values. (b) Change in NPX between baseline and week 12 by two-sided paired BH-adjusted t-test. Red dots denote proteins with BH-adjusted P value < 0.1. Yellow boxes highlight fibrosis-related proteins.

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