Extended Data Fig. 7: Serum proteins with changes in expression associated with changes in FVC with rentosertib treatment. | Nature Medicine

Extended Data Fig. 7: Serum proteins with changes in expression associated with changes in FVC with rentosertib treatment.

From: A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial

Extended Data Fig. 7

(a) PandaOmics analysis of published RNA-seq gene expression datasets profiling patients with IPF and healthy individuals of four top proteomics hit genes in our trial cohort. (b) Correlation analysis of protein abundance of genes previously associated with lung function and IPF TFS with change in FVC from week 0 to week 12, treatment regimen, and time on treatment. n = 43 patient at each visit, and the P value was calculated by two-sided Pearson correlation analysis; n = 11 patients in Placebo, n = 11 patients in 30 QD; n = 11 patients in 30 BID, n = 10 patients in 60 QD. P values calculated by paired t-test.

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