Extended Data Fig. 4: Changes in additional lung function metrics after 12 weeks of treatment with rentosertib. | Nature Medicine

Extended Data Fig. 4: Changes in additional lung function metrics after 12 weeks of treatment with rentosertib.

From: A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial

Extended Data Fig. 4

(a) Absolute change in DLCO ± 95% CI. (b) Absolute Change in DLCO (% Predicted) ± SE, ANCOVA Model with Multiple Imputation assuming missing at random (MAR). (c) Absolute change in percent predicted HGB-corrected DLCO (%) ± SD. (d) Absolute change in FEV1 ± SD. (e) Mean percent-change in FEV1 ± SD. (f) Absolute change in LCQ score ± SD. (g) Absolute change in LCQ score ± SE by Mixed model for repeated measures (MMRM). (h) Absolute change in 6MWD ± SD. (i) Absolute change in 6MWD ± SE, ANCOVA Model with Multiple Imputation assuming MAR.

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