Extended Data Fig. 5: Association of rentosertib treatment with PK parameters. | Nature Medicine

Extended Data Fig. 5: Association of rentosertib treatment with PK parameters.

From: A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial

Extended Data Fig. 5

(a) AUC0-t of rentosertib at week 0 and week 12, data are mean ± SD. n = 11 at week 0 and n = 11 at week 12 in 30QD, n = 11 at week 0 and n = 10 at week 12 in 30 BID, n = 10 at week 0 and n = 10 at week 10 in 60 QD. (b) t1/2 of rentosertib at week 0 and week 12, data are mean ± SD. n = 11 at week 0 and n = 11 at week 12 in 30QD, n = 11 at week 0 and n = 10 at week 12 in 30 BID, n = 10 at week 0 and n = 10 at week 10 in 60 QD. (c) Correlation analysis of AUC0-t and change in FVC between week 0 and week 12. (d) Correlation analysis of Ctrough measured throughout the trial and change in FVC between week 0 and week 12. P values calculated by two-sided Spearman correlation analysis.

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